R. Bhat

Ovarian cancer cells exhibit diverse migration strategies on stiff collagenous substrata

This study quantifies how ovarian cancer cells adapt their migration strategies on different stiffness collagen substrates, revealing distinct behaviors between epithelioid and mesenchymal cell lines.

Dicarbonyl stress enhances tumor intravasation

This study shows dicarbonyl stress increases cancer cell intravasation by degrading ECM and promoting endothelial dysfunction in a microfluidic model.

Dicarbonyl stress debilitates mesothelial defense against metastasizing ovarian cancer

This study shows dicarbonyl stress weakens mesothelial barriers, enabling ovarian cancer metastasis, and identifies GLO-1 as a potential therapeutic target.

The ER Thioredoxin-Related Transmembrane Protein TMX2 Controls Redox-Mediated Tethering of ER-Mitochondria Contacts (ERMCS)

This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.

The senescent mesothelial matrix accentuates colonization by ovarian cancer cells

This study shows that senescent mesothelial cells create a matrix that promotes ovarian cancer cell adhesion, spreading, and movement, enhancing metastasis.

Jammed microgel growth medium prepared by flash-solidification of agarose for 3D cell culture and 3D bioprinting

The paper introduces a 3D cell culture and bioprinting medium made by flash-solidification of agarose, aiming to better mimic in vivo conditions.

T-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults

The paper identifies T-cell stress and reticulocyte signatures as markers of severe COVID-19 in older adults, while showing naive T-cell decline is age-related, not disease-specific.

Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synuclein

This study shows that different agitation methods and solution conditions produce distinct amyloid polymorphs of alpha-synuclein, revealing kinetic control over aggregation pathways.

Rheological transition driven by matrix makes cancer spheroids resilient under confinement

This study shows that ovarian cancer spheroids with an ECM coat (blastuloids) are more resilient under confinement than those without (moruloids) due to a rheological transition driven by the ECM-induced lumen.

Galectin-9 signaling drives breast cancer invasion through matrix

This study shows Galectin-9 promotes breast cancer invasion through ECM by enhancing S100A4 expression and FAK signaling.

Interactive dynamics of matrix adhesion and reaction-diffusion predict diverse multiscale strategies of cancer cell invasion

This study models cancer cell invasion modes using a computational framework, revealing how matrix adhesion and reaction-diffusion drive distinct invasive strategies.

The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism

This study shows that the IRE1/XBP1 signaling pathway enhances skeletal muscle regeneration by boosting satellite cell proliferation in a cell non-autonomous way.

Low mammalian species richness is associated with Kyasanur Forest disease outbreak risk in deforested landscapes in the Western Ghats, India

The paper assesses the relationship between mammalian species richness and Kyasanur Forest disease (KFDV) outbreak risk in deforested landscapes of the Western Ghats, finding that low species richness is linked to higher outbreak risk in areas with significant forest loss.

ST6GAL1-mediated heterogeneity in sialic acid levels potentiates invasion of breast cancer epithelia

This study identifies 2,6-linked sialic acid heterogeneity in breast cancer cells and shows that medium-expressing cells exhibit greater ECM adhesion and invasion compared to high-expressing cells, with ST6GAL1 playing a key role.

Distinct evolutionary trajectories in asexual populations through an interplay of their size, resource availability and mutation rates

This study uses digital evolution to show how mutation rates, population size, and resource availability influence evolutionary outcomes in asexual populations, revealing distinct fitness strategies and the emergence of interdependence.

Vortex chip incorporating an orthogonal turn for size-based isolation of circulating cells

The paper introduces a vortex chip with an orthogonal turn to isolate circulating cells based on size at lower flow velocities, demonstrating selective trapping of breast cancer cells in blood.

A dynamical extracellular matrix coat regulates moruloid-blastuloid transitions of ovarian cancer spheroids

This study shows that a dynamic extracellular matrix coat on ovarian cancer spheroids regulates their morphogenesis and adhesion to substrata, affecting metastasis.

Differential levels of dermatan sulfate generate distinct Collagen I gel architectures

This study examines how varying concentrations of dermatan sulfate affect Collagen I gel architecture using imaging techniques.

An interplay between reaction-diffusion and cell-matrix adhesion regulates multiscale invasion in early breast carcinomatosis

This paper introduces a multiscale computational model to study how reaction-diffusion and cell-matrix adhesion regulate breast cancer invasion.

Follicle stimulating hormone is an autocrine regulator of the ovarian cancer metastatic niche through Notch signaling

This study shows that FSH regulates ovarian cancer metastasis via Notch signaling in spheroids, suggesting FSH and Notch as therapeutic targets.

Galectin-1 promotes the invasion of bladder cancer urothelia through their matrix milieu

This study identifies Galectin-1 as a driver of bladder cancer invasion through matrix interactions, showing its role in promoting adhesion, proliferation, and mesenchymal-like phenotypes.