High-throughput organoid screening enables engineering of intestinal epithelial composition
B. E. Mead, K. Hattori, L. Levy, M. Vukovic, D. Sze, J. D. Matute, J. Duan, R. Langer, R. S. Blumberg, J. Ordovas-Montanes, A. K. Shalek, J. M. Karp
This paper develops a high-throughput organoid screening method to identify agents that alter intestinal epithelial composition, finding Xpo1 inhibitors increase Paneth cell abundance.
bioRxiv · Apr 27, 2020Bioengineering