R. Langer

Thermo-Responsive Polymers Targeting Inflammation in Murine Colitis

This study develops thermo-responsive hydrogels that target inflamed colon mucosa for IBD treatment by exploiting charge-mediated interactions and thermo-responsiveness.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

Intracellular Proteomics and Extracellular Vesiculomics as a Metric of Disease Recapitulation in 3D Bioprinted Aortic Valve Arrays

This study compares 3D-bioprinted and 2D models of calcific aortic valve disease using proteomics and vesiculomics to assess disease recapitulation.

Engineered retrovirus-like nanocarriers for messenger RNA delivery into neurons

This paper develops engineered retrovirus-like nanocarriers for efficient mRNA delivery into neurons by modifying extracellular vesicles with Arc protein capsids and RNA elements.

Absorbable Conductive Electrotherapeutic Scaffolds (ACES) for Enhanced Peripheral Nerve Regeneration and Stimulation

This paper introduces ACES, absorbable conductive scaffolds that enhance peripheral nerve regeneration and stimulation in animal models.

Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases

This study designs a CRISPR-Cas9 variant that preferentially uses homology-directed repair over nonhomologous end-joining, enabling precise editing and reducing indels in both dividing and non-dividing cells.

BBB pathophysiology independent delivery of siRNA in traumatic brain injury

This paper develops a nanoparticle platform for BBB-independent siRNA delivery in TBI, achieving higher brain accumulation and gene silencing through surface chemistry and coating density modulation.

Reverse Pneumatic Artificial Muscles for Application in Low-Cost Artificial Respirators

This paper presents a low-cost, portable mechanical ventilator design using reverse pneumatic artificial muscles for volume-controlled ventilation in emergencies.

High-throughput organoid screening enables engineering of intestinal epithelial composition

This paper develops a high-throughput organoid screening method to identify agents that alter intestinal epithelial composition, finding Xpo1 inhibitors increase Paneth cell abundance.

Individualized System for Augmenting Ventilator Efficacy (iSAVE):A Rapidly deployable system to expand ventilator capacity

The paper introduces iSAVE, a system to safely use a single ventilator for multiple patients during ventilator shortages, demonstrating its effectiveness in simulated and pig trials.

Computationally guided high-throughput design of self-assembling drug nanoparticles

This paper develops a high-throughput screening platform with machine learning to design self-assembling drug nanoparticles, identifying 101 novel formulations from 2.1 million combinations.

OrgaQuant: Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks

OrgaQuant is a deep learning tool that automatically locates and quantifies intestinal organoids in brightfield images using a dataset of manually annotated images.

Cartilaginous and osteochondral tissue formation by human mesenchymal stem cells on three-dimensionally woven scaffolds

This study evaluates how human mesenchymal stem cells on 3D woven scaffolds form cartilage and bone tissue in vivo and in vitro, showing that pre-culturing affects tissue type and mineralization.