MicrobiologybioRxiv
Metabolic selection of a homologous recombination mediated loss of glycosomal fumarate reductase in Trypanosoma brucei
M. wargnies, N. Plazolles, R. Schenk…·F. Bringaud
The paper shows that a deletion event between FRDg and FRDm2 genes is selected in PEPCK knockout cells, leading to a non-functional chimeric gene that reduces growth, suggesting FRD's role in ROS production for parasite differentiation.
DOI 10.1016/j.jbc.2021.100548