Cancer BiologybioRxivPreprint
Pediatric glioblastoma - unlike normal cells - are sensitive to the combination of vorinostat and olaparib and to its downstream effector - phosphorylated eIF2α
K. Eytan, Z. Versano, M. Leitner…·M. Yalon
This study identifies that pediatric glioblastoma cells are sensitive to combinations of vorinostat and PARP-1 inhibitors, and to inhibitors of phosphorylated eIF2 dephosphorylation, with potential therapeutic implications.
DOI 10.1101/2020.11.25.397497