Cell BiologybioRxiv
Analysis of the 4q35 chromatin organization reveals distinct long-range interactions in patients affected with Facio-Scapulo-Humeral Dystrophy.
M.-C. Gaillard, N. Broucqsault, J. Morere…·J. Robin
This study examines the 3D chromatin organization of the 4q35 locus in FSHD patients, finding that D4Z4 contractions and SMCHD1 mutations alter spatial gene interactions and expression.