GenomicsGenome BiologyPeer-reviewed
Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution
Maarten M. van Iterson, Erik W. van Zwet, The Bios Consortium…·Bastiaan T. Heijmans
This paper develops a method to control bias and inflation in epigenome- and transcriptome-wide association studies using an empirical null distribution estimated via Bayesian statistics, showing improved power and false positive rate control.
DOI 10.1186/s13059-016-1131-9