Author

Maddalena Staiano

Helmholtz Munich

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Systems Biology· 1

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Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:scRNA-seq· 1 Research Focus:software / tool· 1 Approach:statistical model· 1 Research Focus:trajectory inference· 1

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Antonio ScialdoneiD· 1 shared Marta BiondoiD· 1 shared Matteo OsellaiD· 1 shared Niccolò CironeiD· 1 shared

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2025-2025 · peak 1/yr

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Antonio ScialdoneORCID

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Systems BiologybioRxivPreprintJul 21, 2025

Intrinsic dimensionality of single-cell transcriptomic data reveals potency landscapes during cell reprogramming

Maddalena Staiano, Niccolò Cirone, Marta Biondo…·Antonio Scialdone

The paper introduces IDEAS, a tool for computing intrinsic dimensionality from scRNA-seq data to assess cell potency without clustering, and applies it to reprogramming datasets to study potency changes and trajectories.

DOI 10.1101/2025.07.21.665922

scRNA-seqstatistical model

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