Cancer BiologybioRxivPreprint
Tumor Cell Death Drives Tumor-Promoting IL-6+ iCAF formation via P2X7-activation
Ciarán McDonnell, Valeriya V. Zinina, Amina Othman…·Mark R. Schmitt
The paper shows chemotherapy-induced ATP release from dying pancreatic cancer cells activates P2X7 in stellate cells, promoting IL-6 production and tumor resistance.
DOI 10.64898/2026.03.18.712671