Matrix stiffness modulated release of spheroid-derived extracellular vesicles and discovery of Piezo1 cargo
Maulee Sheth, Manju Sharma, Supasek Kongsomros…·Leyla Esfandiari
This study shows that matrix stiffness modulates EV release and cargo from cancer spheroids, with stiff matrices promoting tumorigenic and metastatic profiles in EVs.