Cell BiologyAmerican Journal of Respiratory Cell and Molecular BiologyPeer-reviewed
Akt Drives TGF-beta-induced Over-secretion of DKK1 and Impairment of Cystic Fibrosis Airway Epithelium Polarity
Tahir Idris, Michaël Bachmann, Marc Bacchetta…·Mehdi Badaoui
This study shows that Akt signaling drives TGF-beta-induced over-secretion of DKK1 and impairs apicobasal polarity in CF airway epithelium, with therapeutic targeting of these pathways restoring polarization.
7 citations