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Marco Lezzerini

Amsterdam UMC Location University of Amsterdam

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Systems Biology· 1

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Organism:C. elegans· 1 Approach:statistical model· 1

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Alyson W. MacInnesiD· 1 shared Georges E. JanssensiD· 1 shared Marte MolenaarsiD· 1 shared Riekelt H. HoutkooperiD· 1 shared Rob JelieriD· 1 shared Toon Santermans· 1 shared

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Alyson W. MacInnesORCID

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Systems BiologybioRxivPreprintApr 26, 2018

Mitochondrial ubiquinone-mediated longevity is marked by reduced cytoplasmic protein translation

Marte Molenaars, Georges E. Janssens, Toon Santermans…·Riekelt H. Houtkooper

This study shows that clk-1 mutations in C. elegans extend lifespan by repressing cytoplasmic protein translation, similar to insulin signaling reductions, and identifies TAF-4 as a repressor of polyribosome formation under these conditions.

DOI 10.1101/308858

C. elegansstatistical model

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