Riekelt H. Houtkooper

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

This study analyzes heart tissue from BTHS patients using integrated omics to identify metabolic and mitochondrial changes associated with the disease.

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

This study investigates the association between kynurenine and NAD+ pathway metabolites and macrophage content and polarization in carotid plaques, finding higher kynurenine levels correlate with M1 macrophages and reduced NAD+.

The paper identifies plasma triacylglycerol (TG) length and saturation levels as markers of healthy aging in humans, showing that higher physical activity is linked to shorter TG chains and more double bonds.

The paper identifies genetic and molecular regulators of lifespan in C. elegans using a recombinant inbred population and validates their relevance to human age-related diseases.

This study shows that mutations in ETFDH and ACADVL, which are involved in long-chain fatty acid oxidation, impair inflammatory responses to LPS by reducing TLR4 expression and cytokine production.

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

This paper identifies a selective HDAC1/2 inhibitor, Cmpd60, that rejuvenates multiple organ systems in aged mice through transcriptional effects mimicking genetic longevity interventions.

The paper uses tracer-based lipidomics to identify two new disease-specific biomarkers for mitochondrial β-oxidation disorders, revealing insights into lipid metabolism and potential diagnostic applications.

The paper integrates multi-omics data from two C. elegans strains to show that doxycycline-induced UPRmt affects mitochondrial function and lifespan through shared and strain-specific pathways.

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.

This study shows glycine supplementation extends C. elegans lifespan and alters gene expression, with effects dependent on the methionine cycle.

COPAL aligns complexome profiles to identify changes in mitochondrial protein complex abundance caused by Barth syndrome mutations.

The paper identifies genetic loci controlling metabolite levels in C. elegans using recombinant inbred lines and QTL mapping.

This study shows that clk-1 mutations in C. elegans extend lifespan by repressing cytoplasmic protein translation, similar to insulin signaling reductions, and identifies TAF-4 as a repressor of polyribosome formation under these conditions.

This study identifies Csde1-bound transcripts in erythropoiesis and shows that Csde1 regulates their expression through effects on mRNA stability and translation.

This study identifies a homozygous ERAL1 mutation as the cause of Perrault syndrome, showing it disrupts mitochondrial ribosome assembly and function.