Cell BiologybioRxivPreprint
G protein-Coupled Receptor Associated Sorting ProteinGASP1 mediated trafficking of the Glucagon Like Peptide-1Receptor contributes to the development of tolerance toincretin drugs
Anirudh Gaur, Caroline M. Keeshen, Madeline King…·Jennifer L. Whistler
This study shows that GASP1-mediated GLP-1R trafficking contributes to tolerance to incretin drugs, suggesting a strategy to prevent tolerance by biasing drug engagement toward G protein signaling.
DOI 10.1101/2024.08.09.607397