Pharmacology & ToxicologyToxicologyPeer-reviewed
Dysregulation of xenobiotic metabolism and mitochondrial dysfunction exacerbate acetaminophen-induced hepatotoxicity in human antigen R-deficient male mice
Natalie Eppler, Elizabeth Jones, Forkan Ahamed…·Yuxia Zhang
This study shows that HuR deficiency in male mice increases susceptibility to APAP-induced liver injury by impairing xenobiotic metabolism and mitochondrial function.
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