Pharmacology & ToxicologyAmerican Journal of Physiology-Cell PhysiologyPeer-reviewed
Modeling statin-induced myopathy with human iPSCs reveals that impaired proteostasis underlies the myotoxicity and is targetable for the prevention
Xiaolin Zhao, Liyang Ni, Miharu Kubo…·Yoshio Yamauchi
This study uses human iPSC-derived myocytes to model statin-induced myopathy, showing statins impair proteostasis via the mevalonate pathway and identify FOXO1 as a target for prevention.
2 citations