Molecular BiologybioRxivPreprint
Targeting the 3' splice site by a decoy oligonucleotide attenuates U2AF1 splicing activity and inhibits leukemia
Carla Azar-Koussa, Marina Sakran, Efraim Rahamim…·Rotem Karni
This paper develops an RNA decoy strategy to inhibit splicing factor activity in leukemia, showing it reduces tumor burden in vivo regardless of spliceosomal mutations.