Cell BiologyCellsPeer-reviewed
MYBPC3 D389V Variant Induces Hypercontractility in Cardiac Organoids
Darshini A. Desai, Taejeong Song, Rohit R. Singh…·Sakthivel Sadayappan
This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.
11 citations