Taejeong Song

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

This study investigates the role of fast Myosin Binding Protein-C (fMyBP-C) in skeletal muscle homeostasis across age and disease states using mouse models, finding it critical for muscle function and showing its potential as a therapeutic target.

This study investigates the molecular mechanisms of HCM caused by the MYBPC3 D389V variant using cardiac organoids and shows hypercontractility and mitochondrial defects that are rescued by a myosin inhibitor.

This study investigates the effects of MyBP-C knockout in skeletal muscle, finding altered length-dependent activation and myofilament structure, with implications for MyBP-C-related diseases.

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

This study identifies sMyBP-C's critical role in skeletal muscle development and function using gene-edited mouse models, showing its necessity for prenatal and postnatal muscle growth and structural integrity.

This study shows that sustained MEK1-ERK1/2 activity in skeletal muscle promotes a fast-to-slow fiber-type switch, suggesting potential therapeutic applications for enhancing muscle metabolic effectiveness.

This study shows that lack of KLF2 in myeloid cells accelerates skeletal muscle regeneration by enhancing inflammation and promoting myogenesis.