GenomicsGenome Biology and EvolutionPeer-reviewed
{Phi}X174 Attenuation by Whole Genome Codon Deoptimization
James T. Van Leuven, Martina M. Ederer, Katelyn Burleigh…·Craig R. Miller
This study shows that systematically introducing synonymous mutations in bacteriophage {Phi}X174 reduces viral fitness, but the effects are non-linear and gene-dependent.