NeurosciencebioRxivPreprint
CRISPR-mediated Stxbp1 gene activation restores Munc18-1 levels in Stxbp1-haploinsufficient mice
Tetsushi Yamagata, Ryu Ikebe, Kenta Kobayashi…·Toshimitsu Suzuki
This study uses CRISPR-ON to increase Stxbp1 expression in a mouse model, restoring Munc18-1 protein levels but not fully reversing disease symptoms.
DOI 10.64898/2026.06.08.730996