BiophysicsbioRxiv
Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy
Masataka Kawana, Saswata S Sarkar, Shirley Sutton…·James Spudich
The paper analyzes biophysical properties of human β-cardiac myosin with HCM-causing converter domain mutations, finding minimal changes or slightly hypo-contractile profiles, contrasting with clinical hyper-contractility.
DOI 10.1126/sciadv.1601959