NeurosciencebioRxivPreprint
High content live profiling reveals concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis.
Arun Pal, Benedikt Kretner, Masin Abo-Rady…·Andreas Hermann
This study shows that C9ORF72 ALS pathogenesis involves both gain and loss of function mechanisms causing axonal organelle trafficking impairment and DNA damage.
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