BiochemistrybioRxivPreprint
A Fluorescence-Based, T5 Exonuclease-Amplified DNA Cleavage Assay for Discovering Bacterial DNA Gyrase Poisons
Matthew Dias, Trisha Chapagain, Fenfei Leng
This paper introduces a fluorescence-based HTS assay using T5 exonuclease to detect bacterial DNA gyrase poisons, validated with a 50-compound library.
DOI 10.1101/2023.10.16.562555