Author

Matthew Knotts

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Biochemistry· 1

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Approach:deep learning· 1 Approach:large language model· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1

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Ada Y. Shaw· 1 shared Chris SanderiD· 1 shared Debora MarksiD· 1 shared Gregg T. BeckhamiD· 1 shared Japheth E. GadoiD· 1 shared Nicholas P. GauthieriD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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1 shared paperBiochemistry

Ada Y. Shaw

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1 paper

Recent·Most cited

BiochemistrybioRxivJun 22, 2023

Machine learning prediction of enzyme optimum pH

Japheth E. Gado, Matthew Knotts, Ada Y. Shaw…·Gregg T. Beckham

This study develops and evaluates machine learning models to predict enzyme optimum pH, finding that language model embeddings significantly improve prediction accuracy, leading to the release of the EpHod model.

DOI 10.1038/s42256-025-01026-6

protein sequencedeep learning

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