Synthetic BiologyACS Synthetic BiologyPeer-reviewed
The E. coli Cas1/2 endonuclease complex reduces CRISPR/Cascade guide array stability
Zhixia Ye, Eirik A. Moreb, Shuai Li…·Michael Lynch
The paper shows that the Cas1/2 endonuclease complex in E. coli causes instability in CRISPR/Cascade guide arrays, and controlled expression of the Cascade operon improves stability.
10 citations