Developmental BiologyThe EMBO JournalPeer-reviewed
REPRESSION BY HDAC3 AND DAX1 MEDIATES LINEAGE RESTRICTION OF EMBRYONIC STEM CELLS
Daniel Olivieri, Eleonora Castelli, Yumiko Kawamura…·Joerg Betschinger
This study identifies Hdac3 and Dax1 as repressors that restrict mESCs from transdifferentiating into extraembryonic endoderm by silencing Gata6 enhancers, while Nr5a2 and Esrrb promote this conversion.
15 citations