Heather Sheppard

This paper develops an AI framework to interpret single-cell RNA-seq data from pediatric solid tumors, identifying tumor-specific surface antigen pairs for targeted therapies.

The paper quantifies the proteomic composition of amyloid plaques in AD models and human brains, revealing stage-dependent remodeling and conserved proteins across species.

This study shows that deleting Regnase-1 in CAR T cells enhances their antitumor activity against osteosarcoma by creating a proinflammatory tumor microenvironment.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

This study identifies therapy-resistant and tumor-acquired cell states in pediatric rhabdomyosarcoma using single-cell RNA sequencing.

This study tests AAV-mediated gene therapy for sialidosis in a mouse model, showing restored NEU1 activity and reduced tissue damage.

This study shows diet-induced obesity in ferrets increases influenza disease severity and transmission due to altered lung microenvironment and reduced antiviral responses.

This paper creates a spatial cell atlas of neuroblastoma, revealing tumor heterogeneity through multi-omics data and identifying spatial compartmentalization and signaling patterns.