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4 papers
Recent·Most cited
Deepak V. Almeida, Paul J. Converse, Courtney Schill…·Eric L. Nuermberger
This study evaluates TBD09's contribution to BPa-based tuberculosis regimens in mice, showing comparable bactericidal and sterilizing activity to linezolid with reduced toxicity.
Sylvie Sordello, Alain Le Coupanec, Zoï Vahlas…·Anna M. Upton
The paper evaluates next-generation TB drug combinations in a mouse model, showing some regimens cure 90% of mice in under 2 months with faster sterilizing efficacy than existing treatments.
Sylvie Sordello, Alessia Tagliavini, Xavier Boulenc…·Anna M. Upton
The paper evaluates 25 tuberculosis drug combinations in a mouse model, finding 15 combinations with T90 <5 months and three top combinations curing 90% of mice in <3 months.
Roberto Visintainer, Anna Fochesato, Daniele Boaretti…·Luca Marchetti
stormTB provides a web-based mPBPK model for simulating anti-TB drug treatments in mice, enabling pharmacokinetic comparisons and supporting 11 drugs.