BiophysicsbioRxivPreprint
Binary Patterning as a Probe of Protein Language Model Representations
Dylan Klein, Michael Hecht, Vikas Nanda
The paper tests if ESM2 captures sequence grammar for binary patterning in four-helix bundles using synthetic sequences and finds it encodes hydrophobic patterning and physicochemical information.
DOI 10.64898/2026.11.11.765943