Author

Michael Tribuzio

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Alison M. SchramiD· 1 shared Britta WeigeltiD· 1 shared Elisa de StanchinaiD· 1 shared Harika GundlapalliiD· 1 shared Heeseon AniD· 1 shared Hilla SolomoniD· 1 shared Jacqueline A.M. SmithiD· 1 shared Julia Meredith· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alison M. SchramORCID

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1 paper

Recent·Most cited

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

Hilla Solomon, Radha Mukherjee, Yu Chi Yang, Julia Meredith, Alison M. Schram, Sang Ah Yi, Xiaoping Chen, Michael Tribuzio, Harika Gundlapalli, Justin Meyerowitz, Elisa de Stanchina, Britta Weigelt, Heeseon An, Simon T. Barry, Jacqueline A.M. Smith, , Neal X. Rosen

This study shows that coexisting PTEN and PIK3CA mutations in endometrial cancers hyperactivate mTORC1, making them sensitive to mTORC1 inhibitors but not PI3K or AKT inhibitors.

bioRxiv · Feb 14, 2026 · PreprintCancer Biology