Author

Xiaoping Chen

Memorial Sloan Kettering Cancer CenterPrimary ORCID profile (0000-0001-8636-0493 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Xiaoping CheniD2 papers · Sun Yat-sen University

Biology Disciplines

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Cancer Biology· 2 Genomics· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1

Frequent Co-Authors

Elisa de StanchinaiD· 2 shared Guan Wang· 2 shared Jiankui HeiD· 2 shared Li Qin· 2 shared Luwen Ning· 2 shared Meng Zhang· 2 shared Neal X. RoseniD· 2 shared Pinghua Liu· 2 shared

Activity by Year

2014-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

Elisa de StanchinaORCID

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Author profile →

5 papers

Recent·Most cited

Angiotensin (1-7)-based Proteomimetic Polymers as Topicals for the Remediation and Repair of the Cornea following Injury

Parisa Foroozandeh, Ashley K. Nensel, Xiaolin Qi, Jessica Marks, Nihal Kaplan, Siwon Park, Xiaoping Chen, Amit Fischer, Maria Telesforo, Robert M. Lavker, Nathan C. Gianneschi, Han Peng

This study develops a proteomimetic polymer based on angiotensin-(1-7) for topical treatment of corneal injury, showing reduced inflammation, edema, and neovascularization in a mouse model.

bioRxiv · Oct 2, 2026 · PreprintBioengineering

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

Hilla Solomon, Radha Mukherjee, Yu Chi Yang, Julia Meredith, Alison M. Schram, Sang Ah Yi, Xiaoping Chen, Michael Tribuzio, Harika Gundlapalli, Justin Meyerowitz, Elisa de Stanchina, Britta Weigelt, Heeseon An, Simon T. Barry, Jacqueline A.M. Smith, , Neal X. Rosen

This study shows that coexisting PTEN and PIK3CA mutations in endometrial cancers hyperactivate mTORC1, making them sensitive to mTORC1 inhibitors but not PI3K or AKT inhibitors.

bioRxiv · Feb 14, 2026 · PreprintCancer Biology

eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer

Jacob A. Boyer, Ezra Y. Rosen, Malvika Sharma, Madeline A. Dorso, Nicholas Mai, Corina Amor, Jason Reiter, Ram Kannan, Sunyana Gadal, Jianing Xu, Matthew M. Miele, Zhuoning Li, Xiaoping Chen, Qing Chang, Fresia G. Pareja, , Neal X. Rosen

This paper identifies eIF4A as a key regulator of ER translation in breast cancer and shows that inhibiting eIF4A, either alone or with fulvestrant, suppresses ER expression and tumor growth in advanced ER+ breast cancer.

Proceedings of the National Academy of Sciences · Jul 21, 2025Peer-reviewedCancer Biology

Quantitative comparison of single-cell sequencing methods using hippocampal neurons

Luwen Ning, Guan Wang, Zhoufang Li, Wen Hu, Qingming Hou, Yin Tong, Meng Zhang, Li Qin, Xiaoping Chen, Heng-Ye Man, Pinghua Liu, Jiankui He

This study compares three single-cell DNA amplification methods in hippocampal neurons, finding MALBAC and WGA4 to be highly reproducible with high success rates and ability to detect copy number variations.

bioRxiv · Apr 21, 2014 · PreprintGenomics

Quantitative comparison of single-cell sequencing methods using hippocampal neurons

Luwen Ning, Guan Wang, Zhoufang Li, Wen Hu, Qingming Hou, Yin Tong, Meng Zhang, Li Qin, Xiaoping Chen, Hengye Man, Pinghua Liu, Jiankui He

bioRxiv · Apr 18, 2014 · PreprintGenomics