Author

Yu Chi Yang

Revolution Medicines (United States)ORCID 0000-0001-8318-1174Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:perturbation response prediction· 2 Approach:benchmark study· 1 Assay:bulk RNA-seq· 1 Organism:mouse· 1

Frequent Co-Authors

Jacqueline A.M. SmithiD· 2 shared Mallika SinghiD· 2 shared A. Cole EdwardsiD· 1 shared Alison M. SchramiD· 1 shared Álvaro Curiel‐GarcíaiD· 1 shared Amanda R. Decker-FarrelliD· 1 shared Amber M. AmparoiD· 1 shared Andrea CalifanoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersCancer Biology

Jacqueline A.M. SmithORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 14, 2026

Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition

Hilla Solomon, Radha Mukherjee, Yu Chi Yang…·Neal X. Rosen

This study shows that coexisting PTEN and PIK3CA mutations in endometrial cancers hyperactivate mTORC1, making them sensitive to mTORC1 inhibitors but not PI3K or AKT inhibitors.

DOI 10.64898/2026.02.12.705558

humanbulk RNA-seq

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Cancer BiologyNaturePeer-reviewedApr 8, 2024

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

Urszula N. Wasko, Jingjing Jiang, Tanner C. Dalton…·Kenneth P. Olive

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

225 citationstop 1%

humanmouse

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