Cancer BiologybioRxivPreprint
Coexistent PTEN and PIK3CA alterations hyperactivate mTORC1 signaling in endometrial cancers and cause their selective sensitivity to mTORC1 inhibition
Hilla Solomon, Radha Mukherjee, Yu Chi Yang…·Neal X. Rosen
This study shows that coexisting PTEN and PIK3CA mutations in endometrial cancers hyperactivate mTORC1, making them sensitive to mTORC1 inhibitors but not PI3K or AKT inhibitors.
DOI 10.64898/2026.02.12.705558