Cancer BiologybioRxivPreprint
Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and Leukemia
Fanny Zhou, Michelle K. Le, Helen C. Wang…·Robert A. J. Signer
This study identifies proteostasis stress as a driver of stem cell aging, clonal hematopoiesis, and leukemia by showing Hsf1's role in both physiological adaptation and pathological clonal expansion.
1 citation