Cancer BiologybioRxivPreprint
Topoisomerase IIIb protects from tumorigenesis and immune dysregulation
Md Rasel Al Mahmud, Simone Andrea Baechler, Anjali Dhall…·Yves G. Pommier
This study shows that Top3b loss accelerates lymphoma development and causes immune dysregulation in mice through R-loop accumulation and immune signaling activation.
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