Cancer BiologybioRxivPreprint
Systems-level properties of EGFR/Ras/ERK signalling amplify local signals to generate gene expressionplasticity
Alexander E. Davies, Taryn E. Gillies, Stefan Siebert…·John G. Albeck
The paper shows that EGFR/Ras/ERK signaling in invasive breast cancer cells produces more dynamic and disordered ERK activity, leading to heterogeneous gene expression compared to non-malignant cells.
DOI 10.1101/466656