Abhineet R. Ram

This study shows that alpelisib, a PI3K inhibitor, increases defective viral genomes and particles in A/H3N2 but decreases total particles in A/H1N1, suggesting host metabolism influences viral defectiveness.

The paper develops a framework to infer ERK signaling dynamics from fixed-cell immunostains by combining machine learning and differential equations, showing that protein levels reflect different activation timescales.

The paper shows pro-inflammatory cytokines induce SPREADs in human airway epithelial cells, correlating with barrier dysfunction, and that anti-inflammatory drugs suppress these SPREADs.

The paper shows that EGFR/Ras/ERK signaling in invasive breast cancer cells produces more dynamic and disordered ERK activity, leading to heterogeneous gene expression compared to non-malignant cells.