Cell BiologyAging CellPeer-reviewed
HLH-30/TFEB rewires the chaperone network to promote proteostasis under conditions of Coenzyme A and Iron-Sulfur Cluster Deficiency
Rewayd Shalash, Dror Michael Solomon, Mor Levi‐Ferber…·Sivan Henis‐Korenblit
The paper shows that reducing Coenzyme A and iron-sulfur cluster levels enhances proteostasis in C. elegans and human cells via HLH-30/TFEB activation of chaperone genes.
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