BiophysicsbioRxivPreprint
Loop-Directed Cofactor Binding Enables Programmable Multico-factor Protein Design
Andrew C. Mutter, Aleksandr Uvaydov, Eskil M. E. Andersen…·Ronald L. Koder
This paper designs proteins with multiple cofactor binding sites by placing histidine ligands in loop regions, enabling precise control over cofactor positioning and function.
DOI 10.64898/2026.06.27.734619