Molecular mechanisms of 10-Butyl Ether Minocycline (BEM), a novel non-antibiotic tetracycline, as a potential treatment for inflammatory and neuroimmune-related disorders.
Abdul A. Shaik, Praneetha Panthagani, Xiaobo Liu…·Susan E. Bergeson
This paper investigates the molecular mechanisms of BEM, a non-antibiotic minocycline derivative, showing it retains therapeutic pleiotropy while losing antimicrobial activity, making it a potential treatment for neuroimmune and inflammatory disorders.