Tyk2-mediated signaling promotes the development of autoreactive CD8+ CTLs and autoimmune type 1 diabetes
K. Mine, S. Nagafuchi, S. Akazawa, N. Abiru, H. Mori, H. Kurisaki, Y. Yoshikai, H. Takahashi, K. Anzai
This study shows Tyk2 inhibition reduces autoimmune T1D in NOD mice by impairing CD8+ CTL development and {beta}-cell inflammation.
bioRxiv · Jul 14, 2023 · PreprintImmunology