H. Mori

Control of Physiologic Glucose Homeostasis via the Hypothalamic Modulation of Gluconeogenic Substrate Availability

The paper identifies VMNCckbr neurons that regulate fasting blood glucose by enhancing adipose tissue lipolysis and substrate release via the sympathetic nervous system.

Extracellular vesicle-mediated secretion of chlorophyll biosynthetic intermediates in the cyanobacterium Leptolyngbya boryana

This study characterizes extracellular vesicles (EVs) from cyanobacteria, showing they contain chlorophyll intermediates and may help manage their accumulation.

Enhanced tameness by Limosilactobacillus reuteri from gut microbiota of selectively bred mice

This study shows that Limosilactobacillus reuteri from tamely bred mice increases tameness and oxytocin levels when administered, suggesting a role in domestication.

Tumor microenvironmental determinants of high-risk DCIS progression

This study identifies immune microenvironment features and myoepithelial continuity as key determinants of progression in high-risk DCIS.

Tyk2-mediated signaling promotes the development of autoreactive CD8+ CTLs and autoimmune type 1 diabetes

This study shows Tyk2 inhibition reduces autoimmune T1D in NOD mice by impairing CD8+ CTL development and {beta}-cell inflammation.

Recognition of commensal bacterial peptidoglycans defines Drosophila gut homeostasis and lifespan

This study shows that specific bacterial peptidoglycans from Acetobacter persici shorten Drosophila lifespan and increase intestinal stem cell proliferation via gut receptors, while also enhancing stress resistance.

Identification and characterization of a proliferative cell population in estrogen receptor-positive metastatic breast cancer through spatial and single-cell transcriptomics

The paper identifies a proliferative cell population in ER+ metastatic breast cancer using spatial and single-cell transcriptomics, showing its role in estrogen-dependent growth and clinical outcomes.

Analysis of IGHA1 and other salivary proteins post half marathon in female participants

This study examines changes in salivary proteins, including IGHA1, in female participants before and after a half marathon, finding suppressed antimicrobial proteins and positive correlations among stress markers.

CAPG is required for Ebola virus infection by controlling virus egress from infected cells.

This study identifies CAPG as a host factor required for Ebola virus infection by stabilizing actin filaments and facilitating viral egress from infected cells.

Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

This study shows that BMAd lipolysis is essential for maintaining myelopoiesis, bone mass, and bone regeneration during energy deficits.

AP2/ERF transcription factor NbERF-IX-33 is involved in the regulation of phytoalexin production for the resistance of Nicotiana benthamiana to Phytophthora infestans.

This study identifies NbERF-IX-33 as a transcription factor regulating phytoalexin production in N. benthamiana in response to INF1 treatment from P. infestans.

Highly concentrated trehalose induces transient senescence-associated secretory phenotype in fibroblasts via CDKN1A/p21

High-concentration trehalose induces a beneficial senescence-associated secretory phenotype in fibroblasts via CDKN1A/p21, enhancing wound repair in mice.

A ubiquitously expressed UDP-glucosyltransferase, UGT74J1, controls basal salicylic acid levels in rice

This study identifies UGT74J1 as a key enzyme regulating basal salicylic acid levels in rice, showing that its mutation leads to SA overaccumulation and enhanced disease resistance but also growth defects.

Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.

The paper identifies 389 small molecules and 813 host targets that inhibit SARS-CoV-2 infection through in vitro and in vivo testing, using computational integration of drug activity and cellular networks.

Unique metabolic strategies in Hadean analogues reveal hints for primordial physiology

The paper investigates metabolic strategies in Hadean analogues, revealing unique non-CO2-reducing pathways that may inform primordial physiology.

The molecular and metabolic program for adaptation of white adipocytesto cool physiologic temperatures

This study investigates how white adipocytes adapt to cooler temperatures, finding changes in gene expression, lipid metabolism, and energy source utilization.

Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

This study identifies interacting partners and mechanisms of VemP's translocation-coupled arrest-cancelation in Vibrio alginolyticus.

Reduction of Short-Chain Fatty Acid-Producing Gut Microbiota Leads to Transition from Rapid-Eye-Movement Sleep Behavior Disorder to Parkinson's Disease

The paper analyzes gut microbiota in RBD and PD patients, finding increased Akkermansia and decreased SCFA-producing bacteria in PD, suggesting a link between gut dysbiosis and disease progression.

Reversible auto-inhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation

This study investigates how the α9/H246 loop in BepA regulates its protease activity, revealing a histidine switch mechanism that controls degradation of misassembled LptD.

Diversification of the restriction modification system of Streptococcus pyogenes through its acquisition of mobile elements

The paper analyzes methyltransferase diversity in Streptococcus pyogenes by comparing RM systems across genomes and suggests phage-derived MTases contribute to methylome diversity and gene regulation.

A single CRISPR base editor to induce simultaneous C-to-T and A-to-G mutations

This paper introduces Target-ACE, a CRISPR base editor that induces both C-to-T and A-to-G mutations, showing higher efficiency than using separate editors.