ImmunologybioRxivPreprint
Tyk2-mediated signaling promotes the development of autoreactive CD8+ CTLs and autoimmune type 1 diabetes
K. Mine, S. Nagafuchi, S. Akazawa…·K. Anzai
This study shows Tyk2 inhibition reduces autoimmune T1D in NOD mice by impairing CD8+ CTL development and {beta}-cell inflammation.
DOI 10.1101/2023.07.14.548984