BiophysicsbioRxiv
Investigating the conformational response of the Sortilin receptor upon binding endogenous peptide- and protein ligands by HDX-MS
E. Trabjerg, N. Abu-Asad, Z. Wan…·K. D. Rand
This study uses HDX-MS to analyze how Sortilin's conformation changes upon binding different endogenous ligands, revealing distinct conformational impacts and a potential link between ligand binding and a remote domain.
DOI 10.1016/j.str.2019.04.006