Systematic profiling of the acetyl lysine machinery reveals a role for MAPKAPK2 in bromodomain inhibitor resistance
P.-E. Kougnassoukou Tchara, J. Loehr, L. Germain, Z. Steinhart, B. Gonzalez-Badillo, A. Lashgari, F. J. M. Chartier, M. Tucholska, S. Picaud, J. D. R. Knight, S. Angers, N. Bisson, C. R. Goding, E. Audet-Walsh, P. Filippakopoulos, , J.-P. Lambert
This study maps the acetyl lysine machinery interactions and identifies MAPKAPK2 as a factor contributing to resistance to BET bromodomain inhibitors in melanoma.
bioRxiv · Jul 22, 2024 · PreprintCancer Biology