Author

S. Angers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 3 Biochemistry· 1 Pathology· 1

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Research Focus:cell type annotation· 6 Approach:genetic perturbation / CRISPR· 6 Organism:human· 6 Research Focus:differential expression· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

G. Macleod· 4 shared N. Rajakulendran· 3 shared S. Lin· 3 shared Z. Steinhart· 3 shared J. Adams· 2 shared S. O'Brien· 2 shared A. Bell· 1 shared A. H. Luchman· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersCell Biology

G. Macleod

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

CRISPR Screening in Tandem with Targeted mtDNA Damage Reveals WRNIP1 Essentiality

T. Sack, P. Dhavarasa, D. Szames, S. O'Brien, S. Angers, S. O. Kelley

The paper uses mtDNA-damaging agents and CRISPR screening to identify genes essential for mtDNA damage response, finding WRNIP1 essential for mtDNA repair and mitochondrial turnover.

bioRxiv · Oct 3, 2023Biochemistry

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

Targeting the dependence on PIK3C3-mTORC1 signaling in dormancy-prone breast cancer cells blunts metastasis initiation

I. E. Elkholi, A. Robert, C. Malouf, H. Kuasne, S. Drapela, G. Macleod, S. Hebert, A. Pacis, V. Calderon, C. L. Kleinman, A. P. Gomes, J. A. Aguirre-Ghiso, M. Park, S. Angers, J.-F. Cote

This study identifies Pik3c3 as a vulnerability in dormancy-prone breast cancer cells, showing its inhibition reduces metastasis in preclinical models.

bioRxiv · Aug 2, 2023Cancer Biology

SCF-FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination

S. O'Brien, S. Kelso, Z. Steinhart, S. Orlicky, M. Mis, Y. Kim, S. Lin, F. Sicheri, S. Angers

This study identifies CCNL1 as a new substrate of SCF-FBXW7 and shows its role in regulating G2-M progression through ubiquitination, revealing a potential therapeutic target in cancer.

bioRxiv · Sep 26, 2022Cancer Biology

Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography

S. Hu, S. Liu, B. Yu, M. Poddar, S. Singh, C. Cao, J. McGaughey, A. Bell, L. L. Blazer, J. Adams, S. Sidhu, S. Angers, S. P. Monga

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

bioRxiv · Mar 18, 2022Pathology

Genome-wide in vivo screen of circulating tumor cells identifies SLIT2 as a regulator of metastasis

F. Xia, Y. Ma, K. Chen, B. Duong, S. Ahmed, R. Atwal, D. Philpott, T. Ketela, J. Pantea, S. Lin, S. Angers, S. Kelley

This study identifies SLIT2 as a regulator of metastasis through a genome-wide CRISPR screen of circulating tumor cells in a mouse model.

bioRxiv · Aug 20, 2021Cancer Biology

The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.

M. Ahmadi, G. MacLeod, N. Rajakulendran, M. Kosic, A. Yang, F. Molaei, S. Lin, Z. Steinhart, N. I. Park, P. B. Dirks, S. Angers

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

bioRxiv · May 4, 2021 · PreprintCell Biology

Generation of a New Frizzled 2 Flox Mouse Model to Clarify Its Role in Development

M. N. Michalski, C. R. Diegel, Z. A. Zhong, K. Suino-Powell, L. Blazer, J. Adams, VAI Vivarium and Transgenics Core, I. Beddows, K. Melcher, S. S. Sidhu, S. Angers, B. O. Williams

The paper generates a new Fzd2 flox mouse model to investigate tissue-specific roles of Fzd2, resolving contradictions in previous global knockout studies.

bioRxiv · Jan 27, 2021 · PreprintCell Biology

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

P. Guilhamon, M. M. Kushida, A. Nikolic, D. Singhal, G. MacLeod, S. A. M. Tonekaboni, F. M. Cavalli, C. Arlidge, N. Rajakulendran, N. Rastegar, X. Hao, R. Hassam, L. J. Smith, H. Whetstone, F. J. Coutinho, , M. Lupien

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.

bioRxiv · Mar 13, 2020 · PreprintCancer Biology