Decreased Colonic Activin Receptor Like Kinase 1 Disrupts Epithelial Barrier integrity and is associated with a poor clinical outcome in Crohns disease
T. Toyonaga, B. P. Keith, J. Barrow, M. S. Schaner, E. A. Wolber, C. Beasley, J. Huling, Y. Wang, N. L. Allbritton, N. Chaumont, T. S. Sadiq, M. J. Koruda, R. Rahbar, T. S. Furey, P. Sethupathy, S. Z. Sheikh
This study identifies ALK1 as a target of miR-31-5p in CD, showing that decreased ALK1 disrupts epithelial barrier integrity and correlates with poor clinical outcomes.
bioRxiv · Feb 21, 2020Cell Biology