P. Sethupathy

Multi-omic study of genome-edited human colonoid models of colorectal cancer reveal genotype-specific patterns of microRNA regulation

This study uses genome-edited human colonoids to identify genotype-specific miRNA regulation patterns in colorectal cancer, highlighting potential therapeutic targets.

DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma

This paper identifies LINC00473 as a downstream mediator of DNAJB1-PRKACA fusion in fibrolamellar carcinoma, showing it promotes tumor growth and alters mitochondrial function.

CDK7 is a Novel Therapeutic Vulnerability in Fibrolamellar Carcinoma

This study identifies CDK7 as a therapeutic target in fibrolamellar carcinoma by showing its activation in FLC cells and efficacy of CDK7 inhibitors in patient-derived models.

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism

This study shows that extracellular vesicles from obese women's breast adipose tissue promote mitochondrial metabolism and proliferation in ER+ breast cancer cells.

miR-29 is an important driver of aging-related phenotypes

This study identifies miR-29 as a key driver of aging-related phenotypes by showing its upregulation in aging models and its ability to induce aging traits when overexpressed.

Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles

The paper uses genome-edited colorectal cancer organoids to identify microRNA expression patterns linked to specific mutation profiles and shows miR-24-3p's role in promoting cancer cell survival.

Chemical, molecular, and single cell analysis reveal chondroitin sulfate proteoglycan aberrancy in fibrolamellar carcinoma

This study identifies increased chondroitin sulfate proteoglycan levels in fibrolamellar carcinoma through gene expression, mass spectrometry, and single-cell sequencing.

DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling

The paper engineers a DNAJB1-PRKACA fusion in HEK293T cells to study its oncogenic effects, finding LINC00473 overexpression dependent on PKA signaling.

Vertical Sleeve Gastrectomy Induces Enteroendocrine Cell Differentiation of Intestinal Stem Cells Through Farnesoid X Receptor Activation

This study shows vertical sleeve gastrectomy increases enteroendocrine cells via FXR activation in intestinal stem cells, using RNAseq and organoid experiments.

Ozone-induced changes in murine lung extracellular vesicle number and small RNA content

This study shows ozone exposure increases extracellular vesicle numbers and alters miRNA content in mouse lung BALF, with potential regulatory roles for specific miRNAs in airway macrophage responses.

AGO HITS-CLIP in Adipose Tissue Reveals miR-29 as a Post-Transcriptional Regulator of Leptin

The paper uses HITS-CLIP to identify miR-29 as a key post-transcriptional regulator of leptin in adipose tissue, with implications for obesity treatment.

Decreased Colonic Activin Receptor Like Kinase 1 Disrupts Epithelial Barrier integrity and is associated with a poor clinical outcome in Crohns disease

This study identifies ALK1 as a target of miR-31-5p in CD, showing that decreased ALK1 disrupts epithelial barrier integrity and correlates with poor clinical outcomes.

Hotspots of aberrant enhancer activity in fibrolamellar carcinoma reveal molecular mechanisms of oncogenesis and intrinsic drug resistance

This study identifies aberrant enhancer activity in fibrolamellar carcinoma, revealing molecular mechanisms of oncogenesis and drug resistance, and suggests new therapeutic targets.