BiochemistrybioRxivPreprint
Allosteric activation of VCP, a AAA unfoldase, by small molecule mimicry
N. H. Jones, Q. Liu, L. Urnavicius…·T. M. Kapoor
This paper identifies VA1, a small molecule that activates VCP/p97, and reveals its allosteric mechanism through cryo-EM structures and mutagenesis studies.
DOI 10.1101/2023.10.02.560478